Neural patterning Deconstructing the organizer
نویسندگان
چکیده
منابع مشابه
Requirement for anti-dorsalizing morphogenetic protein in organizer patterning
The amphibian Spemann organizer is subdivided in trunk and head organizer and it is unclear how this division is regulated. The Xenopus trunk organizer expresses anti-dorsalizing morphogenetic protein (ADMP), a potent organizer antagonist. We show that ADMP represses head formation during gastrulation and that its expression is activated by BMP antagonists. A specifically acting dominant-negati...
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The formation of the vertebrate body axis during gastrulation strongly depends on a dorsal signaling centre, the Spemann organizer as it is called in amphibians. This organizer affects embryonic development by self-differentiation, regulation of morphogenesis and secretion of inducing signals. Whereas many molecular signals and mechanisms of the organizer have been clarified, its function in an...
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Space, time, and causality provide a natural structure for organizing our experience. These abstract categories allow us to think relationally in the most basic sense; understanding simple events requires one to represent the spatial relations among objects, the relative durations of actions or movements, and the links between causes and effects. The present fMRI study investigates the extent t...
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After nerve injury maladaptive changes can occur in injured sensory neurons and along the entire nociceptive pathway within the CNS, which may lead to spontaneous pain or pain hypersensitivity. The resulting neuropathic pain syndromes present as a complex combination of negative and positive symptoms, which vary enormously from individual to individual. This variation depends on a diversity of ...
متن کاملAntagonism within and around the organizer: BMP inhibitors in vertebrate body patterning.
The vertebrate organizer has been of intense interest since its discovery in amphibia by Spemann and Mangold in the early 1920s (Ref. 1). The organizer was operationally defined as a piece of tissue that can induce a duplicated dorsal body axis and head when transplanted into the ventral side of a host embryo. The original Spemann and Mangold organizer experiment provided the first convincing d...
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ژورنال
عنوان ژورنال: Nature
سال: 1998
ISSN: 0028-0836,1476-4687
DOI: 10.1038/35761